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ABN326 Anti-CAPS-2 Antibody

Anti-CAPS-2 detects levels of CAPS-2 proteins & has been published & validated for use in WB & IHC.

Anti-CAPS-2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: CADPS2, CAPS2 UniProt Number: Q86UW7
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ABN326
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN326
      DescriptionAnti-CAPS-2 Antibody
      Alternate Names
      • Calcium-dependent secretion activator 2
      • CADPS2
      • CAPS-2
      Background InformationCAPS-2 and the related protein CAPS-1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS-1, numerous isoforms of CAPS-2 are known to exist. These isoforms show distinct expression patterns in the brain. For example, CAPS2b showed high expression in the developing cerebellum. Furthermore, one version of CAPS-2 mRNA that lacks exon 3 is detected in some autistic patients, suggesting that the differential expression pattern of CAPS-2 is involved in neuronal development.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CAPS-2 detects levels of CAPS-2 proteins & has been published & validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot Analysis: 1 µg/mL from a representative lot detected CAPS-2 in 10 µg/mL of human brain tissue lysate.

      Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected CAPS-2 in rat cerebellum tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human CAPS-2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody is predicted to be specific to CAPS-2 and not recognize CAPS-1.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • CADPS2
      • CAPS2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~160 kDa observed. Uncharacterized bands may appear at ~40 kDa, ~50 kDa, and ~210 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse brain tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected CAPS-2 in 10 µg/mL of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN326 04053252831089