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ABE280 Anti-Ars2 Antibody

Use Anti-Ars2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect Ars2 also known as Serrate RNA effector molecule homolog, Arsenite-resistance protein 2.

Anti-Ars2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: RNA Metabolism & Binding Proteins Gene Symbol: SRRT, ARS2, ASR2 UniProt Number: Q9BXP5
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ABE280
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE280
      DescriptionAnti-Ars2 Antibody
      Alternate Names
      • Serrate RNA effector molecule homolog
      • Arsenite-resistance protein 2
      Background InformationAs a component of the nuclear RNA cap-binding complex (CBC), Ars2 is known to play a critical role in miRNA biogenesis by stabilizing and linking capped primary miRNA transcripts with the primary miRNA processing complex containing DROSHA and DGGR8. Unlike other CBC components, Ars2 expression also plays an important role in cell proliferation. In particular, depletion of Ars2 is shown to reduce the levels of several miRNAs, such as miR-21, let-7, and miR-155, which are implicated in cellular transformation.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEK293 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-Ars2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect Ars2 also known as Serrate RNA effector molecule homolog, Arsenite-resistance protein 2.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: A representative lot from an independent laboratory detected Ars2 in IP. (Alex Achille, Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA).
      Biological Information
      ImmunogenLinear peptide corresponding to human Ars2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SRRT
      • ARS2
      • ASR2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.

      SUBUNIT STRUCTURE: Interacts with NCBP1 and DROSHA. Interacts with CASP8AP2 and ERBB4.

      TISSUE SPECIFICITY: Ubiquitously expressed.
      Molecular Weight~120 kDa observed. Uncharacterized bands at ~78 kDa and 48 kDa may be observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Ars2 in 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE280 04053252535291