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AB3784P-I Anti-Adiponectin Antibody

Detect adiponectin using this rabbit Anti-Adiponectin polyclonal antibody, Cat. No. AB3784P-I, validated for use in Immunohistochemistry and Western Blotting.

Anti-Adiponectin Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: ADIPOQ, ACDC, ACRP30, ADPND, APM1, GBP28 UniProt Number: Q15848
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AB3784P-I
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3784P-I
      ReplacesAB3784P
      DescriptionAnti-Adiponectin Antibody
      Alternate Names
      • Adiponectin
      • 30 kDa adipocyte complement-related protein
      • ACRP30
      • Adipocyte complement-related 30 kDa protein
      • Adipocyte
      • C1q and collagen domain-containing protein
      • Adipose most abundant gene transcript 1 protein
      • apM-1
      • Gelatin-binding protein
      Background InformationAdiponectin (UniProt Q15848; also known as 30 kDa adipocyte complement-related protein, ACRP30, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the ADIPOQ (also known as ACDC, ACRP30, ADPND, APM1, GBP28) gene (Gene ID 9370) in human. Adipokines are adipose tissue-secreted factors that are involved in vascular function and metabolic disease. While most adipokines are proinflammatory and directly responsible for the development of the chronic inflammatory state in obesity, adiponectin is an adipokine with anti-inflammatory and insulin-sensitizing properties. Adiponectin mediates its biological activity via adiponection receptor proteins 1 & 2 (AdipoR1 & AdipoR2). Both AdipoR1 and AdipoR2 are reported to be ubiquitously expressed with the highest expression in skeletal muscle and liver, respectively. Circulating adiponectin levels are reduced in obesity and type II diabetes, whereas weight loss elevates serum levels of adiponectin. Likewise, adiponectin overexpression is reported to alleviate metabolic dysfunction independent of weight loss in both genetic and diet-induced animal models of obesity. Aadiponectin deficiency is associated with various clinical cardiovascular disorders including myocardial infarction, peripheral artery disease, and endothelial dysfunction. Adiponectin is produced with a signal peptide sequence (a.a. 1-18 in human and rat sequence; a.a. 1-17 in mouse), which is removed postranslationally to yield the mature protein with a collagen-like domain (a.a. 42-107 in human and rat, a.a. 45-110 in mouse) and a C1q domain (a.a. 108-244 in human and rat, a.a. 111-247 in mouse).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect adiponectin using this rabbit Anti-Adiponectin polyclonal antibody, Cat. No. AB3784P-I, validated for use in Immunohistochemistry and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected adiponectin in human heart, kidney, and uterus tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human adiponectin C1q domain (globular domain) fragment.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody targets the C1q domain (globular domain) of human adiponectin.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ADIPOQ
      • ACDC
      • ACRP30
      • ADPND
      • APM1
      • GBP28
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~32 kDa oberved. Target band size appears larger than the calculated molecular weight of 26.41/24.54 kDa (with/without signal peptide a.a. 1-18 sequence) due to posttranslational modifications. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting of human plasma proteins.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected adiponectin in 10 µg of human plasma proteins.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB3784P-I 04054839112393