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ABD133 Anti-ACVR1B Antibody

Anti-ACVR1B Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in western blotting.

Anti-ACVR1B Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Pluripotent & Early Differentiation Gene Symbol: ACVR1B UniProt Number: P36896
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ABD133
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABD133
      DescriptionAnti-ACVR1B Antibody
      Alternate Names
      • Activin A receptor type IB
      • Activin receptor-like kinase 4
      • Activin receptor type 1B precursor
      • ACTR-IB
      • ACVRLK4
      • ALK4
      • ALK-4
      • Serine/threonine-protein kinase receptor R2
      • SKR2
      Background InformationActivin receptor type-1B (ACVR1B) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. ACVR1B is known to form activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Within this receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors (including ACVR1B) act as downstream transducers of activin signals. Activins play role in many physiological and pathological processes including neuronal differentiation and neuronal survival, wound healing, extracellular matrix production, hair follicle development and cycling, FSH production, immunosuppression and carcinogenesis. ACVR1B is expressed highly in systemic sclerosis patient fibroblasts which suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. ACVR1B is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human kidney tissue lysate
      PresentationPurified rabbit polyclonal PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ACVR1B Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human ACVR1B.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • ACVR1B
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~70 kDa observed. Uniprot describes 5 isoforms ranging between ~52 kDa and ~62 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting/Peptide Inhibition Assay in human kidney tissue lysate.

      Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected ACVR1B in 15 µg human kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABD133 04053252912245