Millipore Sigma Vibrant Logo

208721 ALLM - CAS 110115-07-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
110115-07-6C₁₉H₃₅N₃O₄S

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
208721-25MGCN
Limited Availability
Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 25 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewCell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.
      Catalogue Number208721
      Brand Family Calbiochem®
      SynonymsCalpain Inhibitor II
      References
      ReferencesRavid, T., et al. 2000. J. Biol. Chem. 275, 35840.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
      Koohmaraie, M. 1992. Biochemie 74, 239.
      Pinter, M., et al. 1992. Biochemistry 31, 8201.
      Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
      Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
      Product Information
      CAS number110115-07-6
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₉H₃₅N₃O₄S
      Chemical formulaC₁₉H₃₅N₃O₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcalpain-1
      Primary Target K<sub>i</sub>120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
      Purity>95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceN-Acetyl-Leu-Leu-Met
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      208721-25MGCN 04055977202670