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100073 15-PGDH Inhibitor - CAS 1239610-60-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1239610-60-6C₁₉H₂₃NO₄S

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100073-10MGCN
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      Description
      OverviewA cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.
      Catalogue Number100073
      Brand Family Calbiochem®
      Synonyms5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
      References
      ReferencesWu, Y., et al. 2011. J. Med. Chem. 54, 5260.
      Product Information
      CAS number1239610-60-6
      FormYellow solid
      Hill FormulaC₁₉H₂₃NO₄S
      Chemical formulaC₁₉H₂₃NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      100073-10MGCN 04055977226195