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Beyond binding capacity: Chromatography resin manufacturers must find balance

Issue: August 24, 2015
| Category: Downstream




For many years, large-scale chromatography resins have been sold with much emphasis on binding capacity. However, it is important for chromatography resins to demonstrate a balance between capacity and selectivity with productivity and quality. A recent GEN article discussed this trend with several industry experts.

Calculated binding capacity for ion exchange resins is a key piece of information to provide to customers, but it is not necessarily the most important piece. "If you bind such quantities of protein, you will have elution issues and reduced selectivity. That is why we are not aiming at improving binding capacity. We're looking for higher selectivity," according to Matthias Jöhnck, Ph.D., head of chromatography R&D at Merck, who was interviewed in the article.

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