Mobius® FlexReady Solutions
Speed Your Drug to the Clinic and the Market, Safely and Reliably
The Mobius® FlexReady Solutions offer you the flexibility to build an entire downstream single-use process train or incorporate individual unit operations for chromatography, clarification, ultrafiltration/diafiltration and virus filtration, to meet your unique processing challenges. This innovative single-use platform is designed to enable you to install equipment, configure applications and validate your processes quickly and easily.
Clarification
The ultimate goal of clarification is to prepare the cell culture for downstream chromatography and purification. Mobius® single-use manufacturing offers a range of products, services and solutions to meet your particular clarification challenges. You can select from a range of single-use options including mixers, integrated filtration platforms, connectors, storage containers and hardware.
The Mobius® FlexReady Solution for Clarification is an easy-to-use system featuring an optimized single-use flowpath designed to fully support your clarification needs. It features Merck’s innovative, high-performance Millistak+® Pod disposable depth filters which are ideally suited for primary and secondary clarification.
The Mobius® FlexReady Solution for Clarification consists of single-use Flexware® assemblies, innovative separation devices and process-ready hardware systems to deliver optimal operational flexibility, from process development to clinical production to small-scale commercial manufacturing.
- Fast setup of hardware with easy installation of optimally designed Flexware® assemblies
- Single-use flow paths provides maximum adaptability to your changing operational needs
- Pre-designed and optimized solution for confidence and peace of mind
Tangential Flow Filtration
The Mobius® FlexReady Solution with Smart Flexware™ Assemblies for TFF is a fully automated system designed to achieve optimum performance during the purification of MAbs, vaccines, plasma and therapeutic proteins. The system features our leading Pellicon® cassettes and capsules. These advanced, high-performance devices are ideal for today’s higher titer therapeutic antibodies as well as the more demanding filtration processes that require higher operating pressures, temperatures and caustic cleaning regimes.
- Standard hardware platform supports multi-unit operation, multi-product and multiscale production maximizing the flexibility of high-value investments
- Smart Flexware™ single-use assemblies provide ease-of-use, robust reproducibility, elimination of carryover from previous batches
- Full process automation enables you to easily and reproducibly produce clinical and preclinical scale quantities of high-value drug products
- Closed mode of operation is possible with specifically designed flowpath and equipment, reducing contamination risk while increasing flexibility and efficiency
- Comprehensive services ensure rapid implementation and optimized performance
- Supports our industry leading devices
Virus Filtration
As a drug manufacturer you are required to ensure the virus safety of the biological therapeutics you have under development. Mobius® single-use manufacturing can help you meet your virus clearance requirements by providing not only the integrated filtation platforms but also the mixers, connectors, storage containers and hardware that will continue to provide you with the ability to process at increased throughputs.
The Mobius® FlexReady Solution for Virus Filtration is an easy-to-use system featuring an optimized single-use flowpath designed to fully support your parvovirus filtration needs. It features Viresolve® Pro Modus devices, a next-generation parvovirus safety solution delivering robust parvovirus clearance at pilot and medium volume processing.
The Mobius® FlexReady Solution for Virus Filtration consists of single-use Flexware® assemblies, innovative Viresolve Pro Modus devices and process-ready hardware systems to deliver optimal operational flexibility.
- Fast setup of hardware with easy installation of optimally designed Flexware® assemblies
- Single-use flow paths provides maximum adaptability to your changing operational needs
- Pre-designed and optimized solution for confidence and peace of mind