CoPrime® Biochromatography Process-Scale System

Optimized separation and purification for your chromatography process

The CoPrime® Biochromatography System is a fully-automated and configurable chromatography system for biopharmaceutical manufacturing and process-scale applications.

Designed to achieve optimum separation and purification of monoclonal antibodies, vaccines, plasma and therapeutic proteins, the CoPrime® offers greater gradient accuracy across an extended flow-rate window allowing for the use of a wider range of column sizes without the need to change out systems.

The innovative system design includes industry leading NovAseptic® valves to ensure zero dead legs, low hold-up volume and easier cleanability. Common Control Platform® Software provides recipe driven automation, including easy process monitoring and control, recipe creation and data security, simplifying software management, eliminating manual operations and reducing the risks of process variability and errors. A full offering of services, including installation and qualification, maintenance and gradient testing, is also available.

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Learn more about how the CoPrime® Biochromatography Process-Scale System can optimize your separation and purification process.

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CoPrime® system overview

Benefits of the CoPrime® system

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To meet your unique processing requirements, choose from a list of configurable options to build the system that best meets your needs. 

Configure to meet your purification requirements...

Select from the options below to add to the CoPrime® base platform to best meet your unique chromatography processing requirements. 

CoPrime® Options
Option 1: 5 inlet manifold on 1 pump for multiple buffer processing	Option 8: Post-column pH conductivity A conductivity sensor (with temperature compensation) and a pH sensor are fitted in the same flow cell, which is integrated in line between the column and outlet ports. Two ranges of conductivity are defined, one for the process and another for cleaning.
Option 2: Second pump with 2 inlets enabling: Mixing of two products with a regulated flow rate ratio (2% accuracy of the measured value from 180 L/h to 1200 L/h) Linear gradient, from 10% to 90%, according to a rated slope based on flow rate or conductivity (closed control loop: 2% accuracy of the measured value on volume or 2% accuracy of the full scale on conductivity) Step gradient, from 10% to 90%, according to set points on flow rate or conductivity (closed control loop: 2% accuracy of the measured value on flow or 2% accuracy of the full scale on conductivity)	Option 9: Post-column UV dual wavelength With this option, a mono-wavelength UV absorption sensor, Optek® AF45 sensor, or a dual-wavelength with an Optek® AF46 sensor is proposed.
Option 3: Mass flowmeter One mass flowmeter is set up between the pump and the bubble trap for monitoring and regulation of the flow fed to the column. Note: This option includes only one flowmeter. If option 2 (second pump) is selected, the flowmeter option is to be selected twice. The mass flowmeter option excludes the mag flowmeter option.	Option 10: Five outlets Three additional 3/4 in. outlet ports with NovAseptic® valves are added downstream of the column to separate different fractions.
Option 4: Valve block of pre-column filter either disposable or in a housing Note: Filter and housing not included.	Option 11: CIP manifold for cleaning the entire system (excluding the column) in CIP, from one single inlet to one single outlet
Option 5: Valve block and pre-column filter housing Note: Series 3000 housing 20 in. I/O TC 3/4 in. — Type 226 Code 7, Recessed Base	Option 12: Feedback switches on NovAseptic® valve With this option, every valve is mounted with an integrated position feedback switch. Closed position is physically detected.
Option 6: Pre-column pH and conductivity A conductivity sensor (with temperature compensation) and a pH sensor are fitted in the same flow cell, which is integrated in line between the filter and the column.	Option 13: Electromagnetic flowmeter The performance of the flowmeter is dependent on the conductivity of the product. Product conductivity must be greater than 5 μS/cm for liquids, in general, and greater than 10 μS/cm for demineralized water.
Option 7: HETP inlet block valve This option enables injection of the HETP sample as close as possible to the column inlet, through a NovAseptic® divert valve. Note: It is possible to perform an HETP sequence using an inlet port instead of the dedicated divert valve.	Option 14: Filter hoods The addition of stainless steel filter hoods on the enclosure filters and fan allows an IP rating of IPx5.