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554720 trans-Retinoic Acid - CAS 302-79-4 - Calbiochem

Potent modulator of growth and differentiation. Inhibits melanocyte adhesion, motility, and growth.

trans-Retinoic Acid - CAS 302-79-4 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Tretinoin, ATRA, Vitamin A Acid

554720
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
302-79-4C₂₀H₂₈O₂

Products

Numero di catalogoConfezionamento Qtà/conf
554720-500MG Bottiglia di vetro 500 mg
Description
OverviewPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells. PROTECT FROM AIR.
Catalogue Number554720
Brand Family Calbiochem®
SynonymsTretinoin, ATRA, Vitamin A Acid
References
ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
Labbaye, C., et al. 1993. Blood 81, 475.
Sakashita, A., et al. 1993. Blood 81, 1009.
Situ, R., et al. 1993. Dermatology 186, 38.
Tini, M., et al. 1993. Genes Develop. 7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
Sharpe, C.R. 1991. Neuron 7, 239.
Thaller, C. and Eichele, G. 1990. Nature 345, 815.
Product Information
CAS number302-79-4
FormYellow solid
Hill FormulaC₂₀H₂₈O₂
Chemical formulaC₂₀H₂₈O₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by assay
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSVH6475000
Safety Information
R PhraseR: 22-36/37/38-63

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
Possible risk of harm to the unborn child.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
554720-500MG 04061838431332

Documentation

trans-Retinoic Acid - CAS 302-79-4 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

trans-Retinoic Acid - CAS 302-79-4 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
554720

Riferimenti bibliografici

Panoramica delle referenze
Tosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
Labbaye, C., et al. 1993. Blood 81, 475.
Sakashita, A., et al. 1993. Blood 81, 1009.
Situ, R., et al. 1993. Dermatology 186, 38.
Tini, M., et al. 1993. Genes Develop. 7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
Sharpe, C.R. 1991. Neuron 7, 239.
Thaller, C. and Eichele, G. 1990. Nature 345, 815.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-October-2007 RFH
SynonymsTretinoin, ATRA, Vitamin A Acid
DescriptionPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number302-79-4
RTECSVH6475000
Chemical formulaC₂₀H₂₈O₂
Structure formulaStructure formula
Purity≥95% by assay
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 8165
ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
Labbaye, C., et al. 1993. Blood 81, 475.
Sakashita, A., et al. 1993. Blood 81, 1009.
Situ, R., et al. 1993. Dermatology 186, 38.
Tini, M., et al. 1993. Genes Develop. 7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
Sharpe, C.R. 1991. Neuron 7, 239.
Thaller, C. and Eichele, G. 1990. Nature 345, 815.