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506181 p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

506181
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Tabella delle specifiche principali

Empirical Formula
C₁₅₀H₂₂₇N₅₇O₃₂S₂

Products

Numero di catalogoConfezionamento Qtà/conf
506181-500UG Fiala di plastica 500 μg
Description
OverviewThe p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
Catalogue Number506181
Brand Family Calbiochem®
SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
References
ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
Schwarze, S.R., et al. 1999. Science 285, 1569.
Product Information
ATP CompetitiveN
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Applicationp75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
Biological Information
Primary TargetBlocker of MAG- and Nogo-induced inhibition of neurite outgrowth
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
disulfide bond (12-26)
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
506181-500UG 04055977272413