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324516 eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem

eEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).

eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954

324516
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Tabella delle specifiche principali

CAS #Empirical Formula
142557-61-7C₁₃H₁₅N₅O₃

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Numero di catalogoConfezionamento Qtà/conf
324516-10MG Bottiglia di vetro 10 mg
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Description
OverviewA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Catalogue Number324516
Brand Family Calbiochem®
Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
References
ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
Product Information
CAS number142557-61-7
FormOff-white powder
Hill FormulaC₁₃H₁₅N₅O₃
Chemical formulaC₁₃H₁₅N₅O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationeEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).
Biological Information
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
324516-10MG 04055977197310