Millipore Sigma Vibrant Logo
Attenzione: Ci siamo trasferiti. Non è più possibile acquistare i prodotti Merck Millipore nel sito MerckMillipore.comPer saperne di più

681672 Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Wnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

681672
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
19309-14-9C₁₆H₁₄O₄

Products

Numero di catalogoConfezionamento Qtà/conf
681672-2MG 2 mg
Description
OverviewCardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
Catalogue Number681672
Brand Family Calbiochem®
SynonymsWnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
References
Product Information
CAS number19309-14-9
FormOrange-yellow to amber solid
Hill FormulaC₁₆H₁₄O₄
Chemical formulaC₁₆H₁₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
681672-2MG 04055977225204

Documentation

Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
681672
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2010 RFH
SynonymsWnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
DescriptionCardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was recently identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCa-dependent pathway, rather than a GSK-3&beta:-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
FormOrange-yellow to amber solid
CAS number19309-14-9
Chemical formulaC₁₆H₁₄O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling