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681673 Wnt Antagonist III, Box5 - Calbiochem

Wnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.

Wnt Antagonist III, Box5 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Wnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist

681673
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₃₀H₅₀N₆O₁₃S₂

Products

Numero di catalogoConfezionamento Qtà/conf
681673-10MG Bottiglia di vetro 10 mg
Description
OverviewA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
Catalogue Number681673
Brand Family Calbiochem®
SynonymsWnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
References
ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
Product Information
FormWhite lyophilized solid
Hill FormulaC₃₀H₅₀N₆O₁₃S₂
Chemical formulaC₃₀H₅₀N₆O₁₃S₂
Quality LevelMQ100
Applications
ApplicationWnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
681673-10MG 04055977225211

Documentation

Wnt Antagonist III, Box5 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Wnt Antagonist III, Box5 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
681673

Riferimenti bibliografici

Panoramica delle referenze
Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-December-2010 RFH
SynonymsWnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
DescriptionA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
FormWhite lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₅₀N₆O₁₃S₂
Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
Purity≥90% by HPLC
SolubilityDMSO (50 mg/ml) or H₂O (4 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.