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681535 Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

681535
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Tabella delle specifiche principali

CAS #Empirical Formula
5119-48-2C₂₈H₃₈O₆

Products

Numero di catalogoConfezionamento Qtà/conf
681535-1MG Fiala di plastica 1 mg
681535-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Catalogue Number681535
Brand Family Calbiochem®
References
ReferencesMohan, R., et al. 2004. Angiogenesis 7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.
Product Information
CAS number5119-48-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₈H₃₈O₆
Chemical formulaC₂₈H₃₈O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetA steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Primary Target IC<sub>50</sub>12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSKE7288500
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
681535-1MG 04055977260113
681535-5MG 04055977260120