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681525 Wiskostatin - CAS 253449-04-6 - Calbiochem

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly.

Wiskostatin - CAS 253449-04-6 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: N-WASP (neural Wiskott Aldrich syndrome protein)
681525
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
253449-04-6C₁₇H₁₈Br₂N₂O

Products

Numero di catalogoConfezionamento Qtà/conf
681525-1MG Fiala di plastica 1 mg
681525-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
Catalogue Number681525
Brand Family Calbiochem®
References
ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
Product Information
CAS number253449-04-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₁₈Br₂N₂O
Chemical formulaC₁₇H₁₈Br₂N₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetN-WASP (neural Wiskott Aldrich syndrome protein)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
681525-1MG 04055977260090
681525-5MG 04055977260106

Documentation

Wiskostatin - CAS 253449-04-6 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Wiskostatin - CAS 253449-04-6 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
681525

Riferimenti bibliografici

Panoramica delle referenze
Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-April-2008 RFH
DescriptionA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of neural Wiskott Aldrich Syndrome protein (N-WASP). Reported to bind to N-WASP, stabilize the auto-inhibited conformation, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number253449-04-6
Chemical formulaC₁₇H₁₈Br₂N₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.