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681641 Wee1 Inhibitor II - CAS 622855-50-9 - Calbiochem

The Wee1 Inhibitor II, also referenced under CAS 622855-50-9, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Wee1 Inhibitor II - CAS 622855-50-9 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione

Primary Target: Wee1
681641
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
622855-50-9C₂₄H₁₉ClN₂O₃

Products

Numero di catalogoConfezionamento Qtà/conf
681641-1MG Fiala di plastica 1 mg
Description
OverviewA pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
Catalogue Number681641
Brand Family Calbiochem®
Synonyms6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
References
ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
Product Information
CAS number622855-50-9
ATP CompetitiveN
FormBrown solid
Hill FormulaC₂₄H₁₉ClN₂O₃
Chemical formulaC₂₄H₁₉ClN₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetWee1
Primary Target IC<sub>50</sub>59 nM against Wee1
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
681641-1MG 04055977260199

Documentation

Wee1 Inhibitor II - CAS 622855-50-9 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Wee1 Inhibitor II - CAS 622855-50-9 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
681641

Riferimenti bibliografici

Panoramica delle referenze
Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
DescriptionA pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number622855-50-9
Chemical formulaC₂₄H₁₉ClN₂O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.