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681629 W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM).

W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl

Primary Target: Myosin light chain kinase
681629
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
61714-27-0C₁₆H₂₁ClN₂O₂S · HCl

Products

Numero di catalogoConfezionamento Qtà/conf
681629-10MG Fiala di plastica 10 mg
Description
OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).
Catalogue Number681629
Brand Family Calbiochem®
SynonymsN-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl
References
ReferencesCaulfield, M.P., et al. 1991. Neurosci. Lett. 125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther. 251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem. 96, 1721.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.
Product Information
CAS number61714-27-0
ATP CompetitiveN
FormOff-white crystalline solid
Hill FormulaC₁₆H₂₁ClN₂O₂S · HCl
Chemical formulaC₁₆H₂₁ClN₂O₂S · HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMyosin light chain kinase
Primary Target IC<sub>50</sub> 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQK0786000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
681629-10MG 04055977260144

Documentation

W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
681629

Riferimenti bibliografici

Panoramica delle referenze
Caulfield, M.P., et al. 1991. Neurosci. Lett. 125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther. 251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem. 96, 1721.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-January-2010 RFH
SynonymsN-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl
DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM) and myosin light chain kinase (IC50 = 51 µM).
FormOff-white crystalline solid
CAS number61714-27-0
RTECSQK0786000
Chemical formulaC₁₆H₂₁ClN₂O₂S · HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (5 mg/ml), DMF, or warm Ethanol
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Standard Handling
ReferencesCaulfield, M.P., et al. 1991. Neurosci. Lett. 125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther. 251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem. 96, 1721.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

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Categorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors