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681636 W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl

Primary Target: mlck
681636
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
88519-57-7C₁₄H₁₇ClN₂O₂S . HCl

Products

Numero di catalogoConfezionamento Qtà/conf
681636-1MG Fiala di plastica 1 mg
Description
OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).
Catalogue Number681636
Brand Family Calbiochem®
SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
References
ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Product Information
CAS number88519-57-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₁₇ClN₂O₂S . HCl
Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetmlck
Primary Target IC<sub>50</sub>58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase
Purity≥98% by HPLC and single spot by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
681636-1MG 04055977260168

Documentation

W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
681636

Riferimenti bibliografici

Panoramica delle referenze
Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-January-2010 RFH
SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).
FormWhite solid
CAS number88519-57-7
Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
Structure formulaStructure formula
Purity≥98% by HPLC and single spot by TLC
SolubilityH₂O (35 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Standard Handling
ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

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Categorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors