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672315 Ursolic Acid - CAS 77-52-1 - Calbiochem

A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities.

Ursolic Acid - CAS 77-52-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII

672315
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
77-52-1C₃₀H₄₈O₃

Products

Numero di catalogoConfezionamento Qtà/conf
672315-50MG Bottiglia di vetro 50 mg
Description
OverviewA cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
Catalogue Number672315
Brand Family Calbiochem®
Synonyms3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
References
ReferencesLi, Y., et al. 2010. Int. J. Cancer 127, 462.
Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
Jung, S.H., et al. 2007. Biochem. J. 403, 243.
Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
Shishodia, S., et al. 2003. Cancer Res. 63, 4375.
Product Information
CAS number77-52-1
FormWhite powder
Hill FormulaC₃₀H₄₈O₃
Chemical formulaC₃₀H₄₈O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by GC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
672315-50MG 04055977184136

Documentation

Ursolic Acid - CAS 77-52-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Ursolic Acid - CAS 77-52-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
672315

Riferimenti bibliografici

Panoramica delle referenze
Li, Y., et al. 2010. Int. J. Cancer 127, 462.
Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
Jung, S.H., et al. 2007. Biochem. J. 403, 243.
Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
Shishodia, S., et al. 2003. Cancer Res. 63, 4375.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-December-2023 JSW
Synonyms3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
DescriptionA cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number77-52-1
Chemical formulaC₃₀H₄₈O₃
Structure formulaStructure formula
Purity≥90% by GC
SolubilityDimethylformamide or DMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLi, Y., et al. 2010. Int. J. Cancer 127, 462.
Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
Jung, S.H., et al. 2007. Biochem. J. 403, 243.
Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
Shishodia, S., et al. 2003. Cancer Res. 63, 4375.