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613450 TOFA - CAS 54857-86-2 - Calbiochem

A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis.

TOFA - CAS 54857-86-2 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 5-(Tetradecyloxy)-2-furoic acid

Primary Target: Acetyl-CoA carboxylase (ACC)
613450
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
54857-86-2C₁₉H₃₂O₄

Products

Numero di catalogoConfezionamento Qtà/conf
613450-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
Catalogue Number613450
Brand Family Calbiochem®
Synonyms5-(Tetradecyloxy)-2-furoic acid
References
ReferencesLandree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
Zhou, W., et al. 2003. Cancer Res. 63, 7330.
Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.
Product Information
CAS number54857-86-2
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₉H₃₂O₄
Chemical formulaC₁₉H₃₂O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAcetyl-CoA carboxylase (ACC)
Primary Target IC<sub>50</sub>4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
613450-5MG 04055977263787

Documentation

TOFA - CAS 54857-86-2 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

TOFA - CAS 54857-86-2 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
613450

Riferimenti bibliografici

Panoramica delle referenze
Landree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
Zhou, W., et al. 2003. Cancer Res. 63, 7330.
Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-November-2014 JSW
Synonyms5-(Tetradecyloxy)-2-furoic acid
DescriptionA cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number54857-86-2
Chemical formulaC₁₉H₃₂O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml). Slight warming and sonication may be required for complete solubilization in ethanol.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesLandree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
Zhou, W., et al. 2003. Cancer Res. 63, 7330.
Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.