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614310 TLR3/dsRNA Complex Inhibitor - Calbiochem

TLR3/dsRNA Complex Inhibitor acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM). Selectively antagonizes stimulated TLR3 signaling.

TLR3/dsRNA Complex Inhibitor - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor

614310
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₈H₁₃ClFNO₃S

Products

Numero di catalogoConfezionamento Qtà/conf
614310-10MG Bottiglia di vetro 10 mg
Description
OverviewA thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >> 100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).
Catalogue Number614310
Brand Family Calbiochem®
Synonyms(R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor
References
ReferencesCheng, K., et al. 2011. J. Am. Chem. Soc. 133, 3764.
Product Information
FormWhite solid
Hill FormulaC₁₈H₁₃ClFNO₃S
Chemical formulaC₁₈H₁₃ClFNO₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationTLR3/dsRNA Complex Inhibitor acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM). Selectively antagonizes stimulated TLR3 signaling.
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
614310-10MG 04055977186628

Documentation

TLR3/dsRNA Complex Inhibitor - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

TLR3/dsRNA Complex Inhibitor - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
614310

Riferimenti bibliografici

Panoramica delle referenze
Cheng, K., et al. 2011. J. Am. Chem. Soc. 133, 3764.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-August-2012 JSW
Synonyms(R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor
DescriptionA thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >> 100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₃ClFNO₃S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCheng, K., et al. 2011. J. Am. Chem. Soc. 133, 3764.