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613570 TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem

The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Ant-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)

Primary Target: LPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
613570
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₆₃H₂₆₈N₅₂O₃₈S

Products

Numero di catalogoConfezionamento Qtà/conf
613570-1MG Fiala di plastica 1 mg
Description
OverviewA cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
Catalogue Number613570
Brand Family Calbiochem®
SynonymsAnt-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
References
ReferencesToshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
Fitzgerald, K.A., et al. 2001. Nature 413, 78.
Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
Horng, T., et al. 2001. Nat. Immunol. 2, 835.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₆₃H₂₆₈N₅₂O₃₈S
Chemical formulaC₁₆₃H₂₆₈N₅₂O₃₈S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetLPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
613570-1MG 04055977263558

Documentation

TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
613570

Riferimenti bibliografici

Panoramica delle referenze
Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
Fitzgerald, K.A., et al. 2001. Nature 413, 78.
Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
Horng, T., et al. 2001. Nat. Immunol. 2, 835.

Brochure

Titolo
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2008 RFH
SynonymsAnt-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
DescriptionA synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP; also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₆₃H₂₆₈N₅₂O₃₈S
Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesToshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
Fitzgerald, K.A., et al. 2001. Nature 413, 78.
Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
Horng, T., et al. 2001. Nat. Immunol. 2, 835.