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579052 TAPI-2 - CAS 187034-31-7 - Calbiochem

TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.

TAPI-2 - CAS 187034-31-7 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2

Primary Target: MMPs
579052
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
187034-31-7C₁₉H₃₇N₅O₅

Products

Numero di catalogoConfezionamento Qtà/conf
579052-1MG Fiala di plastica 1 mg
Description
OverviewA hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Also available as a 10 mM solution in H2O (Cat. No. 509612).
Catalogue Number579052
Brand Family Calbiochem®
SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
References
ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Parvathy, S., et al. 1997. Biochem. J. 327, 37.
Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
Product Information
CAS number187034-31-7
ATP CompetitiveN
DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
FormWhite solid
Hill FormulaC₁₉H₃₇N₅O₅
Chemical formulaC₁₉H₃₇N₅O₅
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMPs
Primary Target IC<sub>50</sub>18 µM against angiotensin converting enzyme
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
579052-1MG 04055977265378

Documentation

TAPI-2 - CAS 187034-31-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

TAPI-2 - CAS 187034-31-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
579052

Riferimenti bibliografici

Panoramica delle referenze
Bennett, T.A., et al. 2000. J. Immunol. 164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Parvathy, S., et al. 1997. Biochem. J. 327, 37.
Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
DescriptionA hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number187034-31-7
Chemical formulaC₁₉H₃₇N₅O₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityEthanol (5 mg/ml) or H₂O (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Parvathy, S., et al. 1997. Biochem. J. 327, 37.
Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.