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574713 Syk Inhibitor III - CAS 1485-00-3 - Calbiochem

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Syk Inhibitor III - CAS 1485-00-3 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 3,4-Methylenedioxy-β-nitrostyrene

574713
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Panoramica

Replacement Information

Products

Numero di catalogoConfezionamento Qtà/conf
574713-50MG Fiala di plastica 50 mg
Description
OverviewA cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).
Catalogue Number574713
Brand Family Calbiochem®
Synonyms3,4-Methylenedioxy-β-nitrostyrene
References
ReferencesWang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.
Product Information
CAS number1485-00-3
ATP CompetitiveN
FormYellow to brown solid
Hill FormulaC₉H₇NO₄
Chemical formulaC₉H₇NO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSyk
Primary Target IC<sub>50</sub>2.5 µM against Syk kinase activity
Purity≥98% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSWL5270000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
574713-50MG 04055977189681

Documentation

Syk Inhibitor III - CAS 1485-00-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Syk Inhibitor III - CAS 1485-00-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
574713

Riferimenti bibliografici

Panoramica delle referenze
Wang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-April-2016 JSW
Synonyms3,4-Methylenedioxy-β-nitrostyrene
DescriptionA cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).
FormYellow to brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1485-00-3
RTECSWL5270000
Chemical formulaC₉H₇NO₄
Structure formulaStructure formula
Purity≥98% by GC
SolubilityDMSO (25 mg/ml). Use only fresh DMSO.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesWang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.