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531889 STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem

STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: c[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP

531889
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
1441190-66-4C₂₀H₂₄N₁₀O₁₃P₂ (free acid)

Products

Numero di catalogoConfezionamento Qtà/conf
5318890001 Bottiglia di vetro 500 μg
Description
OverviewA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531889
Brand Family Calbiochem®
Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
References
ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
Zhang, X., et al. 2013. Mol. Cell. 51, 226.
Wu, J., et al. 2013. Science. 339, 26.
Product Information
CAS number1441190-66-4
FormWhite solid
Hill FormulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Primary TargetSTING
Primary Target K<sub>i</sub>4 nM, EC₅₀
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
5318890001 04055977260014

Documentation

STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
531889

Riferimenti bibliografici

Panoramica delle referenze
Wu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
Zhang, X., et al. 2013. Mol. Cell. 51, 226.
Wu, J., et al. 2013. Science. 339, 26.

Brochure

Titolo
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Informazioni tecniche

Titolo
White Paper: Further considerations of antibody validation and usage.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-December-2014 JSW
Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
DescriptionA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1441190-66-4
Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
Purity≥98% by HPLC
SolubilityH₂O
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
Zhang, X., et al. 2013. Mol. Cell. 51, 226.
Wu, J., et al. 2013. Science. 339, 26.