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573097 STAT3 Inhibitor III, WP1066

STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.

STAT3 Inhibitor III, WP1066: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: STAT3 pathway
573097
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
857064-38-1C₁₇H₁₄BrN₃O

Products

Numero di catalogoConfezionamento Qtà/conf
573097-10MG Bottiglia di vetro 10 mg
Description
OverviewA cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µM in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 µM) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo. Also available in InSolution™ format (Cat. No. 573129.
Catalogue Number573097
Brand Family Calbiochem®
References
ReferencesIwamaru, A., et al. 2007. Oncogene, 26, 2435.
Product Information
CAS number857064-38-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₇H₁₄BrN₃O
Chemical formulaC₁₇H₁₄BrN₃O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSTAT3 pathway
Primary Target IC<sub>50</sub>5.6 and 3.7 µM in inhibiting malignant glioma growth in a viability assay using U87-MG and U373-MG, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
573097-10MG 04055977266382

Documentation

STAT3 Inhibitor III, WP1066 MSDS

Titolo

Scheda di sicurezza (MSDS) 

STAT3 Inhibitor III, WP1066 Certificati d'Analisi

TitoloNumero di lotto
573097

Riferimenti bibliografici

Panoramica delle referenze
Iwamaru, A., et al. 2007. Oncogene, 26, 2435.

Brochure

Titolo
An Introduction to Inhibitors and Their Biological Applications - 1st Edition
Pathways and Biomarkers of JAK/STAT Signaling

Informazioni tecniche

Titolo
JAK/STAT Signaling Research Focus
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-January-2009 RFH
DescriptionA cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µM in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 µM) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number857064-38-1
Chemical formulaC₁₇H₁₄BrN₃O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesIwamaru, A., et al. 2007. Oncogene, 26, 2435.