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559303 SANT-1 - CAS 304909-07-7 - Calbiochem

A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.

SANT-1 - CAS 304909-07-7 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Shh Signaling Antagonist V

Primary Target: Shh (Sonic Hedgehog) signaling pathway
559303
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
304909-07-7C₂₃H₂₇N₅

Products

Numero di catalogoConfezionamento Qtà/conf
559303-5MG Fiala di plastica 5 mg
Description
OverviewA potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay).
Catalogue Number559303
Brand Family Calbiochem®
SynonymsShh Signaling Antagonist V
References
ReferencesChen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Product Information
CAS number304909-07-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₂₇N₅
Chemical formulaC₂₃H₂₇N₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetShh (Sonic Hedgehog) signaling pathway
Primary Target IC<sub>50</sub>20 nM as antagonist of the Shh (Sonic Hedgehog) signaling pathway in the Shh-LIGHT2 assay and in Ptch1-l- cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.



From Catalog:
Desc. Field- added "cell-permeable
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
559303-5MG 04055977192414

Documentation

SANT-1 - CAS 304909-07-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

SANT-1 - CAS 304909-07-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
559303

Riferimenti bibliografici

Panoramica delle referenze
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-October-2007 JSW
SynonymsShh Signaling Antagonist V
DescriptionA potent antagonist of the Sonic Hedgehog (Shh) signaling pathway (IC50 = 20 nM in Shh-LIGHT2 assay and in Ptch1-l-< cells) that acts by binding to Smoothened (Smo; KD = 1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SANT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50 = 30 nM in SmoA1-LIGHT2 assay).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number304909-07-7
Chemical formulaC₂₃H₂₇N₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.



From Catalog:
Desc. Field- added "cell-permeable
Toxicity Standard Handling
ReferencesChen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.