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553014 Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem

The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor

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Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450

Primary Target: Raf Kinase
553014
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Tabella delle specifiche principali

CAS #Empirical Formula
303727-31-3C₂₀H₁₄ClN₃O

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Numero di catalogoConfezionamento Qtà/conf
553014-1MG Fiala di plastica 1 mg
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Description
OverviewA cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM and Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
Catalogue Number553014
Brand Family Calbiochem®
Synonyms2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
References
ReferencesTakle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
Shelton, J.G., et al. 2003. Leukemia 17, 1765.
Product Information
CAS number303727-31-3
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₀H₁₄ClN₃O
Chemical formulaC₂₀H₁₄ClN₃O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetRaf Kinase
Primary Target IC<sub>50</sub>10 nM; Kd = 2.4 nM for B-raf
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
553014-1MG 04055977193428