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553031 RAGE Antagonist Peptide, RAP - Calbiochem

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

RAGE Antagonist Peptide, RAP - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: ELKVLMEKEL

Primary Target: RAGE
553031
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₅₇H₁₀₁N₁₃O₁₇S

Products

Numero di catalogoConfezionamento Qtà/conf
553031-10MG Bottiglia di vetro 10 mg
Description
OverviewAn S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
Catalogue Number553031
Brand Family Calbiochem®
SynonymsELKVLMEKEL
References
ReferencesArumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.
Product Information
FormWhite powder
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₅₇H₁₀₁N₁₃O₁₇S
ReversibleY
Quality LevelMQ200
Applications
Biological Information
Primary TargetRAGE
Primary Target IC<sub>50</sub>2 µ
Purity≥95% by HPLC
Physicochemical Information
Peptide SequenceAc-ELKVLMEKEL-NH2
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
553031-10MG 04055977193473

Documentation

RAGE Antagonist Peptide, RAP - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

RAGE Antagonist Peptide, RAP - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
553031

Riferimenti bibliografici

Panoramica delle referenze
Arumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2012 JSW
SynonymsELKVLMEKEL
DescriptionAn S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
FormWhite powder
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Peptide SequenceAc-ELKVLMEKEL-NH2
Purity≥95% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesArumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.