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540500 Purvalanol A - CAS 212844-53-6 - Calbiochem

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

Purvalanol A - CAS 212844-53-6 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine

Primary Target: Cdc2/cyclin B
540500
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
212844-53-6C₁₉H₂₅ClN₆O

Products

Numero di catalogoConfezionamento Qtà/conf
540500-1MG Fiala di plastica 1 mg
Description
OverviewA potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2/cyclin B; IC50 = 70 nM for Cdk2/cyclin A; IC50 = 35 nM for Cdk2/cyclin E; and IC50 = 75 nM for Cdk5/p35).
Catalogue Number540500
Brand Family Calbiochem®
Synonyms2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
References
ReferencesGray, N.S., et al. 1998. Science 281, 533.
Product Information
CAS number212844-53-6
ATP CompetitiveN
DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
FormOff-white solid
Hill FormulaC₁₉H₂₅ClN₆O
Chemical formulaC₁₉H₂₅ClN₆O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdc2/cyclin B
Primary Target IC<sub>50</sub>4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
540500-1MG 04055977268812

Documentation

Purvalanol A - CAS 212844-53-6 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Purvalanol A - CAS 212844-53-6 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
540500

Riferimenti bibliografici

Panoramica delle referenze
Gray, N.S., et al. 1998. Science 281, 533.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-December-2009 RFH
Synonyms2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
DescriptionA potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2-cyclin B; IC50 = 70 nM for Cdk2-cyclin A; IC50 = 35 nM for Cdk2-cyclin E; and IC50 = 75 nM for Cdk5-p35).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number212844-53-6
Chemical formulaC₁₉H₂₅ClN₆O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesGray, N.S., et al. 1998. Science 281, 533.