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529685 Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem

A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance.

Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147

529685
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Tabella delle specifiche principali

CAS #Empirical Formula
82-89-3C₂₀H₂₅N₃O

Products

Numero di catalogoConfezionamento Qtà/conf
529685-200UG Bottiglia di vetro 200 μg
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Description
OverviewA cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50 = 2.0 µM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC50 ~ 6.0 µM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 µM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.).
Catalogue Number529685
Brand Family Calbiochem®
SynonymsCasein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147
References
ReferencesSchinske, K.A., et al. 2011. Mol. Cancer Ther. 10, 1807.
Chang, C.C., et al. 2011. J. Biosci. Bioeng. 5, 501
Ho, T.F., et al. 2009. Toxicol. Appl. Pharmacol. 235, 253
Soto-Cerrato, V., et al. 2007.Mol. Cancer Ther. 6, 362.
Product Information
CAS number82-89-3
FormDark red solid
Hill FormulaC₂₀H₂₅N₃O
Chemical formulaC₂₀H₂₅N₃O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
529685-200UG 04055977269314