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524488 Phloretin - CAS 60-82-2 - Calbiochem

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM).

Phloretin - CAS 60-82-2 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone

Primary Target: PKC
524488
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
60-82-2C₁₅H₁₄O₅

Products

Numero di catalogoConfezionamento Qtà/conf
524488-200MG Fiala di plastica 200 mg
Description
OverviewA cell-permeable inhibtor of protein kinase C (IC50 = 20-50 µM). Activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca2+ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F2α receptors linked to phospholipase C in astrocytes.
Catalogue Number524488
Brand Family Calbiochem®
Synonyms2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone
References
ReferencesBerry, G.T., et al. 1994. Pediat. Res. 35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
Wang, X., et al. 1993. Biochem. J. 290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.
Product Information
CAS number60-82-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₁₄O₅
Chemical formulaC₁₅H₁₄O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>20-50 µM against protein kinase C
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
524488-200MG 04055977270990

Documentation

Phloretin - CAS 60-82-2 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Phloretin - CAS 60-82-2 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
524488

Riferimenti bibliografici

Panoramica delle referenze
Berry, G.T., et al. 1994. Pediat. Res. 35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
Wang, X., et al. 1993. Biochem. J. 290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-January-2012 JSW
Synonyms2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone
DescriptionA cell-permeable inhibtor of protein kinase C (IC50 = 20-50 µM). Activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca2+ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F2α receptors linked to phospholipase C in astrocytes.
FormWhite solid
CAS number60-82-2
Chemical formulaC₁₅H₁₄O₅
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityAcetone, ethanol, or methanol
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.
Toxicity Irritant
Merck USA index14, 7326
ReferencesBerry, G.T., et al. 1994. Pediat. Res. 35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
Wang, X., et al. 1993. Biochem. J. 290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.