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20-114 PKA Inhibitor Cocktail

PKA Inhibitor Cocktail: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Key Applications: Kinase Assay
20-114
1 mL  
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Key Applications
KA
Description
Catalogue Number20-114
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPKA Inhibitor Cocktail
References
Product Information
Presentation20mM MOPS, pH 7.2, 25mM β-glycerol phosphate, 5mM EGTA, 1mM sodium orthovanadate, 1mM dithiothreitol
Quality LevelMQ100
Applications
Key Applications
  • Kinase Assay
Application NotesFor use in kinase assays.
Biological Information
Entrez Gene Number
Entrez Gene SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene Symbol
  • PRKACA
  • MGC102831
  • MGC48865
  • PKACA
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
SIZE: 351 amino acids; 40590 Da
SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
TISSUE SPECIFICITY: Isoform 2 is sperm specific.
PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated as an inhibitor cocktail
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size1 mL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
20-114 04053252410444

Documentation

PKA Inhibitor Cocktail MSDS

Titolo

Scheda di sicurezza (MSDS) 

PKA Inhibitor Cocktail Certificati d'Analisi

TitoloNumero di lotto
PKA Inhibitor Cocktail - 0702051768 0702051768
PKA Inhibitor Cocktail - 30209 30209
PKA Inhibitor Cocktail - 3256146 3256146
PKA Inhibitor Cocktail - 3660786 3660786
PKA Inhibitor Cocktail - 4105228 4105228
PKA Inhibitor Cocktail - Any-lot Any-lot
PKA Inhibitor Cocktail - JBC1362505 JBC1362505
PKA Inhibitor Cocktail -2472071 2472071
PKA Inhibitor Cocktail -2830230 2830230