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499635 OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem

The OSC Inhibitor, Ro 48-8071, also referenced under CAS 189197-69-1, controls the biological activity of 2,3-oxidosqualene:lanosterol cyclase activity (OSC).

OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate

499635
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
189197-69-1C₂₃H₂₇BrFNO₂• C₄H₄O₄

Products

Numero di catalogoConfezionamento Qtà/conf
499635-10MG Bottiglia di vetro 10 mg
Description
OverviewAn orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~ 6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~ 1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~ 10 µM).
Catalogue Number499635
Brand Family Calbiochem®
Synonyms4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate
References
ReferencesThoma, R., et al. 2004. Nature 432, 118.
Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.
Product Information
CAS number189197-69-1
FormOff-white solid
Hill FormulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
Chemical formulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
499635-10MG 04055977199284

Documentation

OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
499635

Riferimenti bibliografici

Panoramica delle referenze
Thoma, R., et al. 2004. Nature 432, 118.
Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonyms4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate
DescriptionAn orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~10 µM).
FormOff-white solid
CAS number189197-69-1
Chemical formulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesThoma, R., et al. 2004. Nature 432, 118.
Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.