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487960 Nociceptin - CAS 170713-75-4 - Calbiochem

Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1).

Nociceptin - CAS 170713-75-4 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Orphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ

Primary Target: Opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
487960
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
170713-75-4C₇₉H₁₂₉N₂₇O₂₂

Products

Numero di catalogoConfezionamento Qtà/conf
487960-1MG Fiala di plastica 1 mg
Description
OverviewEndogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity on the µ, δ, or κ opioid receptors; however, nanomolar concentrations of nociceptin inhibit forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
Catalogue Number487960
Brand Family Calbiochem®
SynonymsOrphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
References
ReferencesMadeddu, P., et al. 1999. Hypertension 33, 914.
Sandin, J., et al. 1999. NeuroReport 10, 71.
Meunier, J., et al. 1995. Nature 377, 532.
Reinscheid, R.K., et al. 1995. Science 270, 792.
Product Information
CAS number170713-75-4
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₉H₁₂₉N₂₇O₂₂
Chemical formulaC₇₉H₁₂₉N₂₇O₂₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetOpioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
487960-1MG 04055977200447

Documentation

Nociceptin - CAS 170713-75-4 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Nociceptin - CAS 170713-75-4 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
487960

Riferimenti bibliografici

Panoramica delle referenze
Madeddu, P., et al. 1999. Hypertension 33, 914.
Sandin, J., et al. 1999. NeuroReport 10, 71.
Meunier, J., et al. 1995. Nature 377, 532.
Reinscheid, R.K., et al. 1995. Science 270, 792.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
SynonymsOrphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
DescriptionEndogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity at the µ, δ, or κ opioid receptors; however, nanomolar concentrations of Nociceptin inhibit, forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
CAS number170713-75-4
Chemical formulaC₇₉H₁₂₉N₂₇O₂₂
Peptide SequenceH-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
Purity≥98% by HPLC
SolubilityH₂O (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesMadeddu, P., et al. 1999. Hypertension 33, 914.
Sandin, J., et al. 1999. NeuroReport 10, 71.
Meunier, J., et al. 1995. Nature 377, 532.
Reinscheid, R.K., et al. 1995. Science 270, 792.