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480402 NFAT Inhibitor - CAS 249537-73-3 - Calbiochem

The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

NFAT Inhibitor - CAS 249537-73-3 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: MAGPHPVIVITGPHEE

Primary Target: NFAT (Nuclear Factor of Activated T-cells)
480402
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
249537-73-3C₇₅H₁₁₈N₂₀O₂₂S

Products

Numero di catalogoConfezionamento Qtà/conf
480402-500UG Fiala di plastica 500 μg
Description
OverviewA highly selective NFAT (Nuclear Factor of Activated T-cells) inhibitor that interferes with calcineurin-NFAT interaction without affecting calcineurin (Cat. No. 539568) phosphatase activity. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT.
Catalogue Number480402
Brand Family Calbiochem®
SynonymsMAGPHPVIVITGPHEE
References
ReferencesNoguchi, H., et al. 2004. Nat. Med. 10, 305.
Kiani, A., et al. 2001. Blood 98, 1480.
Aramburu, J., et al. 1999. Science 285, 2129.
Product Information
CAS number249537-73-3
ATP CompetitiveN
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₅H₁₁₈N₂₀O₂₂S
Chemical formulaC₇₅H₁₁₈N₂₀O₂₂S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetNFAT (Nuclear Factor of Activated T-cells)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
480402-500UG 07790788050658

Documentation

NFAT Inhibitor - CAS 249537-73-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

NFAT Inhibitor - CAS 249537-73-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
480402

Riferimenti bibliografici

Panoramica delle referenze
Noguchi, H., et al. 2004. Nat. Med. 10, 305.
Kiani, A., et al. 2001. Blood 98, 1480.
Aramburu, J., et al. 1999. Science 285, 2129.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2008 RFH
SynonymsMAGPHPVIVITGPHEE
DescriptionA highly selective NFAT inhibitor that prevents NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells. Does not affect the expression of other cytokines requiring calcineurin, but not NFAT. Inhibits calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts.
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number249537-73-3
Chemical formulaC₇₅H₁₁₈N₂₀O₂₂S
Peptide SequenceH-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
Purity≥95% by HPLC
SolubilityH₂O
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesNoguchi, H., et al. 2004. Nat. Med. 10, 305.
Kiani, A., et al. 2001. Blood 98, 1480.
Aramburu, J., et al. 1999. Science 285, 2129.