481412 Sigma-AldrichNF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem
The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Sinonimi: (E)-2-Fluoro-4ʹ-methoxystilbene
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Panoramica
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Tabella delle specifiche principali
| CAS # | Empirical Formula |
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| 139141-12-1 | C₁₅H₁₃FO |
Products
| Numero di catalogo | Confezionamento | Qtà/conf | |
|---|---|---|---|
| 481412-10MG | Fiala di plastica | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM). |
| Catalogue Number | 481412 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-2-Fluoro-4ʹ-methoxystilbene |
| References | |
|---|---|
| References | Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182. |
| Product Information | |
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| CAS number | 139141-12-1 |
| ATP Competitive | N |
| Form | Crystalline solid |
| Hill Formula | C₁₅H₁₃FO |
| Chemical formula | C₁₅H₁₃FO |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | NF-κB Activation |
| Primary Target IC<sub>50</sub> | 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells. |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Numero di catalogo | GTIN |
| 481412-10MG | 04055977183726 |
Documentation
NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem MSDS
| Titolo |
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NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem Certificati d'Analisi
| Titolo | Numero di lotto |
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| 481412 |
Riferimenti bibliografici
| Panoramica delle referenze |
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| Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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