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480026 NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC₅₀~ 50 µM in HCT116 cells).

NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD

Primary Target: NEMO-binding peptide
480026
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₂₃H₁₉₇N₄₇O₃₂

Products

Numero di catalogoConfezionamento Qtà/conf
480026-5MG Bottiglia di vetro 5 mg
Description
OverviewA cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025).
Catalogue Number480026
Brand Family Calbiochem®
SynonymsNEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
References
ReferencesHong, S., et al. 2012. Mol. Pharm. 9, 1310.
Kim, D., et al. 2006. Exp. Cell Res. 312, 1277.
Product Information
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₂₃H₁₉₇N₄₇O₃₂
Hygroscopic Hygroscopic
ReversibleY
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary TargetNEMO-binding peptide
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide ContentY
Peptide SequenceAc-YGRRARRRARRTALDWSWLQTE-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
480026-5MG 04055977201840

Documentation

NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
480026

Riferimenti bibliografici

Panoramica delle referenze
Hong, S., et al. 2012. Mol. Pharm. 9, 1310.
Kim, D., et al. 2006. Exp. Cell Res. 312, 1277.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-June-2017 JSW
SynonymsNEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
DescriptionA cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025).
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Peptide SequenceAc-YGRRARRRARRTALDWSWLQTE-NH₂
Purity≥95% by HPLC
SolubilityH₂O (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHong, S., et al. 2012. Mol. Pharm. 9, 1310.
Kim, D., et al. 2006. Exp. Cell Res. 312, 1277.