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616387 Nα-Tosyl-Phe Chloromethyl Ketone

Irreversible inhibitor of chymotrypsin.

Nα-Tosyl-Phe Chloromethyl Ketone: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: TPCK

Primary Target: chymotrypsin activity in preparations
616387
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
402-71-1C₁₇H₁₈ClNO₃S

Products

Numero di catalogoConfezionamento Qtà/conf
616387-250MG Fiala di plastica 250 mg
Description
Overview

This product has been discontinued.





Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides (EC50 = 20 µM).
Catalogue Number616387
Brand Family Calbiochem®
SynonymsTPCK
References
ReferencesFearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
Product Information
CAS number402-71-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₁₈ClNO₃S
Chemical formulaC₁₇H₁₈ClNO₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetchymotrypsin activity in preparations
Primary Target IC<sub>50</sub>EC50 = 20 µM in blocking the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXT5613500
Safety Information
R PhraseR: 41

Risk of serious damage to eyes.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
616387-250MG 04055977186314

Documentation

Nα-Tosyl-Phe Chloromethyl Ketone MSDS

Titolo

Scheda di sicurezza (MSDS) 

Nα-Tosyl-Phe Chloromethyl Ketone Certificati d'Analisi

TitoloNumero di lotto
616387

Riferimenti bibliografici

Panoramica delle referenze
Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

Citazioni

Titolo
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•
    Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-September-2008 RFH
    SynonymsTPCK
    DescriptionIrreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharide (EC50 = 20 µM). Suggested working concentration is 10-100 µM.
    FormWhite solid
    CAS number402-71-1
    RTECSXT5613500
    Chemical formulaC₁₇H₁₈ClNO₃S
    Structure formulaStructure formula
    Purity≥98% by TLC
    SolubilityEthanol (5 mg/ml) or Methanol (5 mg/ml)
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
    Toxicity Irritant
    ReferencesFearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
    Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
    Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
    Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
    Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
    Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
    Citation
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•