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FCMAB214P Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2

Milli-Mark Anti-CD117 Antibody, c-kit-PE, clone 104D2 detects level of CD117 & has been published & validated for use in FC.

Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P10721
FCMAB214P
100 tests  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMPhycoerythrinMonoclonal Antibody
Description
Catalogue NumberFCMAB214P
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2
Alternate Names
  • Mast/stem cell growth factor receptor
  • SCFR
  • Tyrosine-protein kinase Kit
  • Proto-oncogene c-Kit
Background InformationCD117 is a 145 kDa transmembrane protein which belongs to the class III receptor tyrosine kinase family. The extracellular region consists of five immunoglobulin-like domains where the second and third loops are thought to be involved in ligand binding (Ashman, 1997; Bühring, 1995). CD117 has been shown to be a marker for tissue mast cells, hematopoietic stem cells, and progenitor cells in normal human bone marrow. The majority of CD117-positive marrow cells (50-70%) co-express CD34 and comprise progenitor cells and their precursors of all hematopoietic lineages. Apart from mast cells, CD117 is essentially absent from mature hematopoietic cells. Although CD117 is primarily a marker for non-lymphoid progenitor cells in the hematopoietic cells/tissues, including melanocytes, embryonic brain, and the reproductive system (Ashman, 1997). Anti-CD117, 104D2, was included in the Sixth International Workshop and Conference on Human Leucocyte differentiation Antigens, and studies by different laboratories confirmed its reactivity with CD117 (Ashman, 1997).
References
Product Information
FormatPhycoerythrin
Control
  • TF-1 cells
PresentationPurified Mouse monoclonal IgG1 conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Quality LevelMQ100
Applications
ApplicationMilli-Mark Anti-CD117 Antibody, c-kit-PE, clone 104D2 detects level of CD117 & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenMOLM-1 megakaryocytic cell line.
Clone104D2
HostMouse
SpecificityAntibody recognizes Human CD117 antigen.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryThis is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (PI3K).

Defects in KIT are a cause of piebaldism. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes
Molecular Weight145 kDa (Ashman, 1997; Buhring, 1995)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using TF-1 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
FCMAB214P 04053252480232

Documentation

Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2 MSDS

Titolo

Scheda di sicurezza (MSDS) 

Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2 Certificati d'Analisi

TitoloNumero di lotto
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 1985163 1985163
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 1987083 1987083
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 1995601 1995601
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 2005384 2005384
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 2059940 2059940
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - NRG1779490 NRG1779490
Milli-Mark™ Anti-CD117, c-kit-PE, clone 104D2 - 3288479 3288479
Milli-Mark™ Anti-CD117, c-kit-PE, clone 104D2 -2505433 2505433
Milli-Mark™ Anti-CD117, c-kit-PE, clone 104D2 -2506577 2506577
Milli-Mark™ Anti-CD117, c-kit-PE, clone 104D2 - 2390560 2390560
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Categorie

Life Science Research > Antibodies and Assays > Primary Antibodies