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444143 MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

444143
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
548472-68-0C₃₀H₃₀Cl₂N₄O₄

Products

Numero di catalogoConfezionamento Qtà/conf
444143-1MG Fiala di plastica 1 mg
Description
OverviewA cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
Catalogue Number444143
Brand Family Calbiochem®
SynonymsMDM2 Inhibitor IV
References
ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.
Product Information
CAS number548472-68-0
ATP CompetitiveN
FormSolid
Hill FormulaC₃₀H₃₀Cl₂N₄O₄
Chemical formulaC₃₀H₃₀Cl₂N₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMDM2
Primary Target IC<sub>50</sub>90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b
Purity≥98% by TLC and HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
444143-1MG 07790788050337

Documentation

MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
444143

Riferimenti bibliografici

Panoramica delle referenze
Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.

Brochure

Titolo
Interactive Pathway Calendar
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-August-2008 RFH
SynonymsMDM2 Inhibitor IV
DescriptionA cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number548472-68-0
Chemical formulaC₃₀H₃₀Cl₂N₄O₄
Structure formulaStructure formula
Purity≥98% by TLC and HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.