Millipore Sigma Vibrant Logo
Attenzione: Ci siamo trasferiti. Non è più possibile acquistare i prodotti Merck Millipore nel sito MerckMillipore.comPer saperne di più

530650 Luciferase Substrate, CycLuc1 - Calbiochem

A synthetic cyclic alkylaminoluciferin with properties superior to D-luciferin. Binds to luciferase with higher affinity.

Luciferase Substrate, CycLuc1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: Luciferase
530650
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₃H₁₁N₃O₂S₂

Products

Numero di catalogoConfezionamento Qtà/conf
5306500001 Bottiglia di vetro 10 mg
Description
OverviewA synthetic cyclic alkylaminoluciferin that exhibits properties that are superior to those of D-luciferin. Binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530650
Brand Family Calbiochem®
References
ReferencesEvans, M., et al. 2014. Nat Methods. 11, 393.
Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.
Product Information
FormYellow powder
Hill FormulaC₁₃H₁₁N₃O₂S₂
Chemical formulaC₁₃H₁₁N₃O₂S₂
Quality LevelMQ100
Applications
Biological Information
Primary TargetLuciferase
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
5306500001 04055977260403

Documentation

Luciferase Substrate, CycLuc1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Luciferase Substrate, CycLuc1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
530650

Riferimenti bibliografici

Panoramica delle referenze
Evans, M., et al. 2014. Nat Methods. 11, 393.
Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2019 JSW
DescriptionA synthetic cyclic alkylaminoluciferin that exhibits properties that are superior to those of D-luciferin. Binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₁₁N₃O₂S₂
Purity≥94% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesEvans, M., et al. 2014. Nat Methods. 11, 393.
Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.