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434610 Leukadherin-1 - CAS 344897-95-6 - Calbiochem

A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fib

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Leukadherin-1 - CAS 344897-95-6 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II

434610
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Tabella delle specifiche principali

CAS #Empirical Formula
344897-95-6C₂₂H₁₅NO₄S₂

Products

Numero di catalogoConfezionamento Qtà/conf
434610-25MG Bottiglia di vetro 25 mg
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Description
OverviewA furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo.
Catalogue Number434610
Brand Family Calbiochem®
SynonymsLA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II
References
ReferencesMaiguel, D., et al. 2011. Sci. Signal. 4, ra57.
Product Information
CAS number344897-95-6
FormRed-brown solid
Hill FormulaC₂₂H₁₅NO₄S₂
Chemical formulaC₂₂H₁₅NO₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
434610-25MG 04055977210217