420202 Sigma-AldrichJMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem
The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Sinonimi: JHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid
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Panoramica
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Tabella delle specifiche principali
| CAS # | Empirical Formula |
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| 1310809-17-6 | C₂₇H₂₉N₃O₆ |
Products
| Numero di catalogo | Confezionamento | Qtà/conf | |
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| 420202-5MG | Bottiglia di vetro | 5 mg |
| Description | |
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| Overview | A substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203). |
| Catalogue Number | 420202 |
| Brand Family | Calbiochem® |
| Synonyms | JHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid |
| References | |
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| References | Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451. |
| Product Information | |
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| CAS number | 1310809-17-6 |
| Form | Off-white powder |
| Hill Formula | C₂₇H₂₉N₃O₆ |
| Chemical formula | C₂₇H₂₉N₃O₆ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Numero di catalogo | GTIN |
| 420202-5MG | 04055977210767 |
Documentation
JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem MSDS
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JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem Certificati d'Analisi
| Titolo | Numero di lotto |
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| 420202 |
Riferimenti bibliografici
| Panoramica delle referenze |
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| Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451. |
Informazioni tecniche
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| White Paper - The Message in the Marks: Deciphering Cancer Epigenetics |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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