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420202 JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem

420202
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
1310809-17-6C₂₇H₂₉N₃O₆

Products

Numero di catalogoConfezionamento Qtà/conf
420202-5MG Bottiglia di vetro 5 mg
Description
OverviewA substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
Catalogue Number420202
Brand Family Calbiochem®
SynonymsJHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid
References
ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.
Product Information
CAS number1310809-17-6
FormOff-white powder
Hill FormulaC₂₇H₂₉N₃O₆
Chemical formulaC₂₇H₂₉N₃O₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
420202-5MG 04055977210767

Documentation

JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420202

Riferimenti bibliografici

Panoramica delle referenze
Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.

Informazioni tecniche

Titolo
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2012 JSW
SynonymsJHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid
DescriptionA substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1310809-17-6
Chemical formulaC₂₇H₂₉N₃O₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.