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420126 JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: JAK-3
420126
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
856436-16-3 C₁₈H₁₃N₃O • MeSO₃H

Products

Numero di catalogoConfezionamento Qtà/conf
420126-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005).
Catalogue Number420126
Brand Family Calbiochem®
References
ReferencesChen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.
Product Information
CAS number856436-16-3
ATP CompetitiveN
FormYellow solid
Hill Formula C₁₈H₁₃N₃O • MeSO₃H
Chemical formulaC₁₈H₁₃N₃O • MeSO₃H
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetJAK-3
Primary Target IC<sub>50</sub>27 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
420126-5MG 04055977188042

Documentation

JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420126

Riferimenti bibliografici

Panoramica delle referenze
Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.

Brochure

Titolo
Pathways and Biomarkers of JAK/STAT Signaling

Informazioni tecniche

Titolo
JAK/STAT Signaling Research Focus
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
DescriptionA cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number856436-16-3
Chemical formulaC₁₈H₁₃N₃O • MeSO₃H
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesChen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.