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420104 JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

420104
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
211555-04-3C₁₆H₁₄BrN₃O₃

Products

Numero di catalogoConfezionamento Qtà/conf
420104-5MG Fiala di plastica 5 mg
Description
OverviewA potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.
Catalogue Number420104
Brand Family Calbiochem®
Synonyms4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
References
ReferencesGhosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.
Product Information
CAS number211555-04-3
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₁₆H₁₄BrN₃O₃
Chemical formulaC₁₆H₁₄BrN₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetJAK-3
Primary Target IC<sub>50</sub>5.6 µM against JAK3
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
420104-5MG 04055977187908

Documentation

JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420104

Riferimenti bibliografici

Panoramica delle referenze
Ghosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.

Informazioni tecniche

Titolo
JAK/STAT Signaling Research Focus
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonyms4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
DescriptionA potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3. Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-jun in DT-40 cells.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number211555-04-3
Chemical formulaC₁₆H₁₄BrN₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGhosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.