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203389 InSolution™Blebbistatin, Racemic - Calbiochem

InSolution™Blebbistatin, Racemic, is a 50 mM in 90% DMSO. A cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis.

InSolution™Blebbistatin, Racemic - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: ATPase
203389
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₈H₁₆N₂O₂

Products

Numero di catalogoConfezionamento Qtà/conf
203389-5MG Fiala di plastica 5 mg
Description
Catalogue Number203389
Brand Family Calbiochem®
References
ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Hill FormulaC₁₈H₁₆N₂O₂
Chemical formulaC₁₈H₁₆N₂O₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™Blebbistatin, Racemic, is a 50 mM in 90% DMSO. A cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis.
Biological Information
Primary TargetATPase
Primary Target IC<sub>50</sub><100 µM inhibiting the ATPase and gliding motility of human platelets
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
203389-5MG 04055977221251

Documentation

InSolution™Blebbistatin, Racemic - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

InSolution™Blebbistatin, Racemic - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
203389

Riferimenti bibliografici

Panoramica delle referenze
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-May-2008 RFH
DescriptionA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
FormLiquid
FormulationA 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₆N₂O₂
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.