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324519 InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

324519
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CAS #Empirical Formula
315706-13-9C₁₈H₁₂Cl₂N₄O₄S

Products

Numero di catalogoConfezionamento Qtà/conf
324519-5MG Bottiglia di vetro 5 mg
Description
OverviewA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.
Catalogue Number324519
Brand Family Calbiochem®
SynonymseIF4F Inhibitor I, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid
References
ReferencesGkogkas, C.G., et al. 2012. Nature 493, 371.
Moerke, N. J., et al. 2007. Cell 128, 257.
Product Information
CAS number315706-13-9
FormLiquid
FormulationA 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)
Hill FormulaC₁₈H₁₂Cl₂N₄O₄S
Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargeteIF4E
Primary Target K<sub>i</sub>25 µ
Purity≥95% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numero di catalogo GTIN
324519-5MG 04055977197341