Millipore Sigma Vibrant Logo
Attenzione: Ci siamo trasferiti. Non è più possibile acquistare i prodotti Merck Millipore nel sito MerckMillipore.comPer saperne di più

553508 InSolution™ Rac1 Inhibitor - Calbiochem

The InSolution™ Rac1Inhibitor, also referenced under CAS 1177865-17-6, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Rac1 Inhibitor - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: Rac1
553508
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₄H₃₅N₇ • 3HCl

Products

Numero di catalogoConfezionamento Qtà/conf
553508-5MG Fiala di plastica 5 mg
Description
Catalogue Number553508
Brand Family Calbiochem®
References
ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
Hill FormulaC₂₄H₃₅N₇ • 3HCl
Chemical formulaC₂₄H₃₅N₇ • 3HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRac1
Primary Target IC<sub>50</sub>~50 µM interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1
Purity≥93% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
553508-5MG 04055977193671

Documentation

InSolution™ Rac1 Inhibitor - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

InSolution™ Rac1 Inhibitor - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
553508

Riferimenti bibliografici

Panoramica delle referenze
Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-December-2010 JSW
DescriptionA cell-permeable pyrimidine compound that specifically inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~ 50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Also shown to effectively inhibit Rac1 and Rac2 activation in Lin- c-kit+ bone marrow cells stimulated with SDF-1α (effective intraperitoneal dose of 1mg/kg). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.
FormLiquid
FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₃₅N₇ • 3HCl
Structure formulaStructure formula
Purity≥93% by HPLC
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.